{"id":857,"date":"2025-04-03T18:44:41","date_gmt":"2025-04-04T03:44:41","guid":{"rendered":"https:\/\/a-rank.top\/ivermectin-or-molnupiravir\/"},"modified":"2025-04-03T18:44:41","modified_gmt":"2025-04-04T03:44:41","slug":"ivermectin-or-molnupiravir","status":"publish","type":"post","link":"https:\/\/a-rank.top\/en\/ivermectin-or-molnupiravir\/","title":{"rendered":"Ivermectin or Molnupiravir"},"content":{"rendered":"<p><iframe loading=\"lazy\" title=\"Ivermectin or Molnupiravir\" width=\"858\" height=\"483\" src=\"https:\/\/www.youtube.com\/embed\/hKa3EZqofNo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>Link to featured video<br \/>\n<iframe loading=\"lazy\" title=\"Updates on Hezekiah and Ben&#039;s condition\" width=\"858\" height=\"483\" src=\"https:\/\/www.youtube.com\/embed\/ctwX1cz_-dw?start=323&#038;feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>Link to Wefwafwa\u2019s channel<br \/>\nhttps:\/\/www.youtube.com\/channel\/UCzsLklGgOttU3Se-WGLp7ow<br \/>\n(he needs more subscribers)<\/p>\n<p>Link to support Wefwafwa\u2019s work in Africa<br \/>\npatreon:https:\/\/www.patreon.com\/awmedicalvideos<\/p>\n<p>Drugs Shown to Inhibit SARS-CoV-2 in COVID-19 Disease: Comparative Basic and Clinical Pharmacology of Molnupiravir and Ivermectin<\/p>\n<p>https:\/\/austinpublishinggroup.com\/pharmacology-therapeutics\/fulltext\/ajpt-v9-id1149.pdf<\/p>\n<p>https:\/\/www.linkedin.com\/in\/leslie-adesuyi-ajayi-md-phd-fbpharmacols-fwacp-69154a38\/<\/p>\n<p>There are still many nations where vaccines are not yet widely available, <\/p>\n<p>There is a gradual shift in focus, to antiviral drugs, <\/p>\n<p>Adjunctive chemoprophylaxis<\/p>\n<p>Active treatment of new SARS-CoV-2 infections<\/p>\n<p>Post -vaccination breakthrough COVID-19 cases<\/p>\n<p>The two ways to get new drugs<\/p>\n<p>Develop novel antiviral drugs for SARS-CoV-2 <\/p>\n<p>Repurpose existing FDA -approved drugs to treat COVID-19<\/p>\n<p>Ivermectin is the most studied \u201crepurposed\u201d medication globally, <\/p>\n<p>in randomized clinical trials, retrospective studies and meta- analyses. <\/p>\n<p>Molnupiravir and Ivermectin Anti-SARS- CoV-2 Mechanisms, Pharmacokinetics and Pharmacodynamics <\/p>\n<p>Molnupiravir is a broad spectrum antiviral agent against SARS- CoV-2, SARS-CoV,<\/p>\n<p>seasonal or pandemic influenza and MERS corona virus<\/p>\n<p>Ivermectin is an FDA-approved, WHO essential drug used as broad spectrum antiparasitic, antibiotic <\/p>\n<p>and which has demonstrated broad spectrum antiviral activity against RNA viruses, including HIV, Zika, MERS corona virus<\/p>\n<p>The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro<\/p>\n<p>https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354220302011<\/p>\n<p>5000-fold inhibition of SARS-CoV-2, (99.98% at 48 hours<\/p>\n<p>The inhibitory concentration IC50 of Molnupiravir shows it to be a more potent anti-SARS-CoV-2 agent, compared to Ivermectin in vitro. <\/p>\n<p>Both molnupiravir and ivermectin are well absorbed after oral dosing<\/p>\n<p>Tmax of molnupiravir being 1-1.75 hours,<\/p>\n<p>With a half life of 7 hours<\/p>\n<p>Tmax of ivermectin is 4-6 hours<\/p>\n<p>Very long half life of 81-91 hours<br \/>\nIvermectin, being lipophilic has a large volume of distribution<\/p>\n<p>Ivermectin has the ability to accumulate in the lungs<\/p>\n<p>The anti-SARS-CoV-2 actions, both of molnupiravir and ivermectin, are dose and concentration dependent<\/p>\n<p>Molnupiravir active metabolite (NHC-5\u2019 Triphosphate), acts as a competitive alternative substrate for viral RNA<\/p>\n<p>causing viral mutagenesis or mutations, which leads to viral error catastrophe and extinction of replication<\/p>\n<p>There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells<\/p>\n<p>Ivermectin, multifarious actions, <\/p>\n<p>Binding to SARS-CoV-2 spike protein S<\/p>\n<p>Reducing cell entry via human ACE2 receptors <\/p>\n<p>Reducing viral transcription<\/p>\n<p>Inhibition of cytokine production and inflammation<br \/>\n(not yet been shown for molnupiravir) <\/p>\n<p>Complimentary pharmacokinetics and pharmacodynamics of the drugs<\/p>\n<p>May be additive or synergistic<\/p>\n<p>This should be further investigated in anti-SARS- CoV-2 antiviral combination therapy.<\/p>\n<p>A combination of molnupiravir with Ivermectin putatively, in effects on RdRP or cytokine release. <\/p>\n<p>Cost<\/p>\n<p>https:\/\/www.who.int\/selection_medicines\/committees\/expert\/21\/reviews\/Ivermectin_Review1.pdf<\/p>\n<p>The cost for a package of 100 tablets of 3 mg ivermectin is $2.96.<\/p>\n<p>Say, 12mg per day for 5 days = $0.53<\/p>\n<p>Safety<\/p>\n<p>http:\/\/www.vigiaccess.org<\/p>\n<p>https:\/\/www.who-umc.org\/vigibase\/vigibase\/<\/p>\n<p>Efficacy<\/p>\n<p>Ivermectin<\/p>\n<p>https:\/\/pubmed.ncbi.nlm.nih.gov\/34145166\/<\/p>\n<p>For deaths, average risk ratio 0.38, (62% benefit) (moderate-certainty evidence<\/p>\n<p>https:\/\/ivmmeta.com<\/p>\n<p>Early treatment <\/p>\n<p>Late treatment<\/p>\n<p>Prophylaxis<\/p>\n<p>https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD015017.pub2\/epdf\/full<\/p>\n<p>Main results, Treating people in hospital with COVID-19<\/p>\n<p>We don&#8217;t know whether ivermectin compared with placebo or usual care, 28 days after treatment:\u2013 <\/p>\n<p>leads to more or fewer deaths<\/p>\n<p>worsens or improves patients&#8217; condition assessed by need for ventilation or oxygen<\/p>\n<p>increases or reduces unwanted events<\/p>\n<p>Preventing COVID-19<\/p>\n<p>We don&#8217;t know whether ivermectin leads to more or fewer deaths compared with no drug<\/p>","protected":false},"excerpt":{"rendered":"<p>Link to featured video Link to Wefwafwa\u2019&#8230; <\/p>","protected":false},"author":1,"featured_media":858,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[503,508,502,501,509,510,506,504,500,505,499,507,498,9],"class_list":["post-857","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivermectin","tag-biology","tag-campbell","tag-disease","tag-health","tag-human-biology","tag-human-body","tag-medical-education","tag-medicine","tag-nclex","tag-nurse-education","tag-nursing","tag-pathophysiology","tag-physiology","tag-9"],"yoast_head":"<!-- This site is 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