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\/>\n\u4f53\u7cfb\u7684\u306a\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff082020\u5e74\uff09\u306b\u3088\u308b\u3068\u3001\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306e\u9ad8\u7528\u91cf\uff08200 \u00b5g\/kg\u8d85\u3001\u307e\u305f\u306f400 \u00b5g\/kg\u8d85\uff09\u306e\u4f7f\u7528\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u3092\u5206\u6790\u3057\u305f\u7d50\u679c\u3001\u6700\u5927800 \u00b5g\/kg\u307e\u3067\u306e\u5358\u56de\u6295\u4e0e\u306b\u304a\u3044\u3066\u3001\u901a\u5e38\u306e\u627f\u8a8d\u7528\u91cf\uff08\u6700\u5927400 \u00b5g\/kg\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6709\u5bb3\u4e8b\u8c61\uff08AE\uff09\u306e\u5168\u4f53\u7684\u306a\u983b\u5ea6\u3084\u91cd\u7be4\u5ea6\u306b\u6709\u610f\u306a\u5dee\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u5831\u544a\u3055\u308c\u305f\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u307b\u3068\u3093\u3069\u304c\u8efd\u5ea6\u307e\u305f\u306f\u4e2d\u7b49\u5ea6\u3067\u3042\u308a\u3001\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u7a00\u3067\u3057\u305f\u3002\u305f\u3068\u3048\u3070\u3001\u3042\u308b\u8a66\u9a13\u3067\u306f\u3001\u91cd\u7be4\u306aAE\u3068\u3057\u3066\u6a19\u6e96\u7528\u91cf\u7fa4\u3067\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u53cd\u5fdc\u304c1\u4f8b\u3001\u9ad8\u7528\u91cf\u7fa4\u3067QTc\u5ef6\u9577\u304c1\u4f8b\u5831\u544a\u3055\u308c\u305f\u306e\u307f\u3067\u3059\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u4e00\u822c\u7684\u306b\u7528\u91cf\u306b\u4f9d\u5b58\u3057\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u30aa\u30f3\u30b3\u30bb\u30eb\u30ab\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3042\u308b\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u9ad8\u7528\u91cf\u7fa4\u3067\u773c\u79d1\u7cfb\u306e\u6709\u5bb3\u4e8b\u8c61\uff08\u4e00\u904e\u6027\u306e\u8996\u899a\u306e\u307c\u3084\u3051\u3001\u76ee\u306e\u75d2\u307f\u3084\u75db\u307f\u3001\u8272\u899a\u7570\u5e38\u306a\u3069\uff09\u306e\u767a\u751f\u7387\u304c\u6709\u610f\u306b\u5897\u52a0\u3059\u308b\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u773c\u79d1\u7cfbAE\u306f\u3059\u3079\u3066\u4e00\u904e\u6027\u3067\u3001\u6570\u65e5\u3067\u5f90\u3005\u306b\u6d88\u5931\u3057\u307e\u3057\u305f\u304c\u3001\u30aa\u30f3\u30b3\u30bb\u30eb\u30ab\u75c7\u306e\u65e2\u5f80\u304c\u3042\u308b\u60a3\u8005\u306b\u5bfe\u3057\u3066\u9ad8\u7528\u91cf\u3092\u4f7f\u7528\u3059\u308b\u969b\u306b\u306f\u7279\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>\u7d50\u8ad6\u3068\u3057\u3066\u3001\u9ad8\u7528\u91cf\u306e\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u6a19\u6e96\u7528\u91cf\u306b\u5339\u6575\u3059\u308b\u5b89\u5168\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5206\u6790\u306b\u5229\u7528\u3067\u304d\u308b\u30c7\u30fc\u30bf\u306e\u5c11\u306a\u3055\u304b\u3089\u3001\u73fe\u6642\u70b9\u3067\u306f\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u7528\u91cf\u3092\u8d85\u3048\u305f\u4f7f\u7528\u3092\u63a8\u5968\u3059\u308b\u306b\u306f\u30c7\u30fc\u30bf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>2. COVID-19\u6cbb\u7642\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7684\u77e5\u898b<br \/>\n\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306eCOVID-19\u5916\u6765\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5927\u898f\u6a21\u306a\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\uff08ACTIV-6\uff09\u306b\u304a\u3044\u3066\u3001\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\uff08400 \u00b5g\/kg\u30923\u65e5\u9593\u6bce\u65e5\u6295\u4e0e\uff09\u3092\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u3001\u75c7\u72b6\u304c\u6301\u7d9a\u7684\u306b\u56de\u5fa9\u3059\u308b\u307e\u3067\u306e\u6642\u9593\u3092\u6709\u610f\u306b\u6539\u5584\u3057\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u9593\u3067\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u306f\u4f4e\u304f\u3001\u540c\u7a0b\u5ea6\u3067\u3057\u305f\uff08\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u3082\u4e21\u7fa4\u30671.2%\u3068\u985e\u4f3c\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306eCOVID-19\u60a3\u8005\u306b\u5bfe\u3057\u3066\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3092\u81e8\u5e8a\u7684\u306b\u652f\u6301\u3057\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nII. \u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u305f\u764c\u306e\u7a2e\u985e\u3068\u30e1\u30ab\u30cb\u30ba\u30e0<br \/>\n\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001\u30c9\u30e9\u30c3\u30b0\u30fb\u30ea\u30dd\u30b8\u30b7\u30e7\u30cb\u30f3\u30b0\uff08\u65e2\u5b58\u85ac\u306e\u8ee2\u7528\uff09\u306e\u5019\u88dc\u3068\u3057\u3066\u3001\u8907\u6570\u306e\u764c\u7a2e\u306b\u5bfe\u3057\u3066\u524d\u81e8\u5e8a\u6bb5\u968e\uff08\u4e3b\u306b\u7d30\u80de\u682a\u307e\u305f\u306f\u52d5\u7269\u30e2\u30c7\u30eb\uff09\u3067\u6297\u816b\u760d\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>1. \u81a0\u82bd\u816b\uff08Glioblastoma, GBM\uff09<br \/>\n\u81a0\u82bd\u816b\u306f\u3001\u8840\u7ba1\u65b0\u751f\u304c\u975e\u5e38\u306b\u591a\u304f\u3001\u6a19\u6e96\u6cbb\u7642\u306b\u9ad8\u5ea6\u306a\u8010\u6027\u3092\u793a\u3059\u60aa\u6027\u8133\u816b\u760d\u3067\u3059\u3002<\/p>\n<p>\u52b9\u679c\u3068\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5177\u4f53\u4f8b<br \/>\n\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001\u81a0\u82bd\u816b\u7d30\u80de\uff08U87\u304a\u3088\u3073T98G\uff09\u306e\u5897\u6b96\u3068\u30b3\u30ed\u30cb\u30fc\u5f62\u6210\u3092\u5f37\u304f\u6291\u5236\u3057\u3001\u52d5\u7269\u30e2\u30c7\u30eb\uff08\u7570\u7a2e\u79fb\u690d\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\uff09\u306b\u304a\u3044\u3066\u3082\u816b\u760d\u306e\u6210\u9577\u3092\u6709\u610f\u306b\u6291\u5236\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>1. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u3068\u9178\u5316\u7684\u30b9\u30c8\u30ec\u30b9\u306e\u8a98\u5c0e: \u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306e\u4f5c\u7528\u306e\u4e2d\u5fc3\u306f\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5de5\u5834\u3067\u3042\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u547c\u5438\u3001\u819c\u96fb\u4f4d\u3001\u304a\u3088\u3073ATP\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u540c\u6642\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\uff08\u6d3b\u6027\u9178\u7d20\u7a2e\u3001ROS\u306e\u4e00\u7a2e\uff09\u306e\u7523\u751f\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\u3053\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u969c\u5bb3\u3068\u9178\u5316\u7684\u30b9\u30c8\u30ec\u30b9\u306e\u8a98\u5c0e\u304c\u3001\u30ab\u30b9\u30d1\u30fc\u30bc\u4f9d\u5b58\u7684\u306a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u4e3b\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3059\u3002<\/p>\n<p>2. Akt\/mTOR\u7d4c\u8def\u306e\u4e0d\u6d3b\u6027\u5316: \u3055\u3089\u306b\u3001\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001\u764c\u7d30\u80de\u306e\u751f\u5b58\u3068\u5897\u6b96\u306b\u95a2\u308f\u308bAkt\/mTOR\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u30ea\u30f3\u9178\u5316\uff08\u6d3b\u6027\u5316\uff09\u3092\u6291\u5236\u3057\u3001\u3053\u306e\u7d4c\u8def\u3092\u4e0d\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002<\/p>\n<p>3. \u8840\u7ba1\u65b0\u751f\u306e\u963b\u5bb3: \u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001\u816b\u760d\u306e\u6210\u9577\u306b\u4e0d\u53ef\u6b20\u306a\u8840\u7ba1\u65b0\u751f\u3082\u6a19\u7684\u3068\u3057\u3001\u30d2\u30c8\u8133\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\uff08HBMEC\uff09\u306b\u304a\u3051\u308b\u6bdb\u7d30\u8840\u7ba1\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u5f62\u6210\u3001\u5897\u6b96\u3001\u304a\u3088\u3073\u751f\u5b58\u3092\u52b9\u679c\u7684\u306b\u963b\u5bb3\u3057\u307e\u3059\u3002<\/p>\n<p>2. \u4e73\u304c\u3093\uff08Breast Cancer\uff09<br \/>\n\u4e73\u304c\u3093\u7814\u7a76\u3067\u306f\u3001\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u967d\u6027\u7d30\u80de\uff08MCF7\uff09\u3084\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u7d30\u80de\uff08MDA MB231\uff09\u306a\u3069\u3001\u591a\u69d8\u306a\u30b5\u30d6\u30bf\u30a4\u30d7\u3067\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306e\u6709\u52b9\u6027\u304c\u691c\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5177\u4f53\u4f8b<br \/>\nA. \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068DNA\u640d\u50b7\u306b\u3088\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e:<br \/>\n1. \u9078\u629e\u7684\u7d30\u80de\u6bd2\u6027: \u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306e\u534a\u6570\u963b\u5bb3\u6fc3\u5ea6\uff08IC50\uff09\u306f\u3001\u5065\u5eb7\u306a\u4e73\u817a\u4e0a\u76ae\u7d30\u80de\u3088\u308a\u3082\u4e73\u304c\u3093\u7d30\u80de\u682a\uff08MCF7, MDA MB231\uff09\u306e\u65b9\u304c\u4f4e\u304f\u3001\u764c\u7d30\u80de\u306b\u5bfe\u3057\u3066\u6bd4\u8f03\u7684\u9ad8\u3044\u9078\u629e\u6027\u3092\u6301\u3064\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>2. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7d4c\u8def\u306e\u6d3b\u6027\u5316: \u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001\u7d30\u80de\u5185\u306e\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u30ec\u30d9\u30eb\u3092\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u5897\u52a0\u3055\u305b\u3001\u540c\u6642\u306b\u6297\u9178\u5316\u9632\u5fa1\u306b\u91cd\u8981\u306a\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\uff08GSH\uff09\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u3053\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f62\u6210\u306b\u3088\u308a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u96fb\u4f4d\uff08MMP\uff09\u304c\u4f4e\u4e0b\u3057\u3001\u6700\u7d42\u7684\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002<\/p>\n<p>3. DNA\u640d\u50b7: \u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u307e\u305f\u3001\u4e73\u304c\u3093\u7d30\u80de\u306b\u304a\u3044\u3066DNA\u640d\u50b7\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u3001\u3053\u308c\u3082\u7d30\u80de\u6b7b\u3092\u5c0e\u304f\u52b9\u7387\u7684\u306a\u8981\u56e0\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002<br \/>\nB. \u5185\u5206\u6ccc\u62b5\u6297\u6027\u4e73\u304c\u3093\u306b\u304a\u3051\u308b\u8ee2\u79fb\u6291\u5236\uff08Wnt\u30b7\u30b0\u30ca\u30eb\uff09:<br \/>\n\u5185\u5206\u6ccc\u62b5\u6297\u6027\u4e73\u304c\u3093\uff08\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u8010\u6027MCF-7\/LCC2\u3001\u30d5\u30eb\u30d9\u30b9\u30c8\u30e9\u30f3\u30c8\u8010\u6027MCF-7\/LCC9\u306a\u3069\uff09\u306b\u5bfe\u3057\u3001\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u7d30\u80de\u306e\u5897\u6b96\u3001\u904a\u8d70\u3001\u304a\u3088\u3073\u6d78\u6f64\u3092\u6291\u5236\u3057\u307e\u3059\u3002<\/p>\n<p>1. EMT\uff08\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\uff09\u306e\u6291\u5236: \u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001\u7d30\u80de\u306e\u79fb\u52d5\u30fb\u8ee2\u79fb\u80fd\u529b\u3092\u9ad8\u3081\u308b\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308b\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\uff08EMT\uff09\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u8ee2\u79fb\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u30d3\u30e1\u30f3\u30c1\u30f3\uff08Vimentin\uff09Snail\u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5b9f\u73fe\u3057\u307e\u3059\u3002<\/p>\n<p>2. Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u963b\u5bb3: \u3053\u306e\u6297\u8ee2\u79fb\u4f5c\u7528\u306f\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u963b\u5bb3\u3092\u4ecb\u3057\u3066\u5a92\u4ecb\u3055\u308c\u307e\u3059\u3002\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001\u8ee2\u79fb\u306b\u95a2\u9023\u3059\u308bWnt\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308bWnt5a\/b\u3001\u304a\u3088\u3073Wnt\u53d7\u5bb9\u4f53\u3067\u3042\u308bLRP6\u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>3. \u5c3f\u8def\u4e0a\u76ae\u304c\u3093\uff08Urothelial Carcinoma: UC\uff09<br \/>\n\u5c3f\u8def\u4e0a\u76ae\u304c\u3093\uff08\u8180\u80f1\u304c\u3093\uff09\u306f\u518d\u767a\u7387\u304c\u9ad8\u304f\u3001\u8ee2\u79fb\u6027\u306e\u5834\u5408\u306b\u6cbb\u7642\u304c\u56f0\u96e3\u3067\u3059\u3002<\/p>\n<p>\u52b9\u679c\u3068\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5177\u4f53\u4f8b<br \/>\n\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001UC\u7d30\u80de\u682a\uff08T24, RT4\uff09\u306e\u7d30\u80de\u5897\u6b96\u3092\u7528\u91cf\u304a\u3088\u3073\u6642\u9593\u4f9d\u5b58\u7684\u306b\u6291\u5236\u3057\u307e\u3059\u3002<\/p>\n<p>1. \u7d30\u80de\u5468\u671f\u306e\u505c\u6b62\u3068\u30ab\u30b9\u30d1\u30fc\u30bc\u4f9d\u5b58\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9: \u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u7d30\u80de\u5468\u671f\u3092G1\u671f\u3067\u505c\u6b62\u3055\u305b\u3001p21\u306e\u5897\u52a0\u3068CDK2, CDK4, \u30b5\u30a4\u30af\u30ea\u30f3D1\u306e\u6e1b\u5c11\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-8\u3001-9\u3001-3\u306e\u6d3b\u6027\u5316\u3092\u4f34\u3046\u30ab\u30b9\u30d1\u30fc\u30bc\u4f9d\u5b58\u6027\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u5916\u56e0\u6027\u7d4c\u8def\u3068\u5185\u56e0\u6027\u7d4c\u8def\u306e\u4e21\u65b9\u3092\u4ecb\u3057\u3066\u751f\u3058\u3001\u5185\u56e0\u6027\u7d4c\u8def\u3067\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u96fb\u4f4d\uff08MMP\uff09\u306e\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>2. JNK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6291\u5236: \u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3001UC\u7d30\u80de\u306b\u304a\u3044\u3066JNK\u304a\u3088\u3073ERK\u7d4c\u8def\u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3057\u307e\u3059\u304c\u3001p38\u7d4c\u8def\u306f\u6291\u5236\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u7279\u306b\u3001JNK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6291\u5236\u304c\u3001\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306b\u3088\u308bUC\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e\u3092\u5a92\u4ecb\u3059\u308b\u91cd\u8981\u306a\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nIII. \u5168\u4f53\u89e3\u8aac\uff1a\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306e\u6297\u764c\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u300c\u30b9\u30a4\u30c3\u30c1\u300d\u3068\u3057\u3066\u306e\u5f79\u5272<\/p>\n<p>\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u304c\u8907\u6570\u306e\u764c\u7d30\u80de\u306b\u5bfe\u3057\u3066\u6297\u816b\u760d\u52b9\u679c\u3092\u793a\u3059\u80cc\u666f\u306b\u306f\u3001\u764c\u7d30\u80de\u304c\u4f9d\u5b58\u3057\u3066\u3044\u308b\u6839\u6e90\u7684\u306a\u751f\u5b58\u30fb\u5897\u6b96\u30b7\u30b9\u30c6\u30e0\u3092\u5d29\u58ca\u3055\u305b\u308b\u3068\u3044\u3046\u3001\u5171\u901a\u3057\u305f\u4f5c\u7528\u6a5f\u5e8f\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n<p>\u764c\u7d30\u80de\u306e\u8106\u5f31\u6027\u3092\u7a81\u304f\u5171\u901a\u30e1\u30ab\u30cb\u30ba\u30e0<br \/>\n\u764c\u7d30\u80de\u306f\u3001\u6025\u901f\u306a\u5897\u6b96\u306e\u305f\u3081\u306b\u3001\u6b63\u5e38\u7d30\u80de\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u5927\u91cf\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\uff08ATP\uff09\u3092\u751f\u7523\u3057\u3001\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u3092\u5e38\u306b\u30aa\u30f3\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306e\u6297\u764c\u4f5c\u7528\u306f\u3001\u3053\u306e\u764c\u7d30\u80de\u7279\u6709\u306e\u4f9d\u5b58\u6027\u3092\u72d9\u3063\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>1. \u30a8\u30cd\u30eb\u30ae\u30fc\u767a\u96fb\u6240\u306e\u7834\u58ca\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a19\u7684\u5316\uff09<br 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\u540c\u6642\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u3067\u5927\u91cf\u306e\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u3092\u767a\u751f\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u767a\u96fb\u6240\u304c\u30aa\u30fc\u30d0\u30fc\u30d2\u30fc\u30c8\u3057\u3066\u6709\u5bb3\u306a\u6392\u30ac\u30b9\u3092\u6492\u304d\u6563\u3089\u3059\u3088\u3046\u306a\u72b6\u614b\u3067\u3059\u3002\u764c\u7d30\u80de\u306f\u5143\u3005ROS\u304c\u591a\u304f\u3001\u6297\u9178\u5316\u529b\u304c\u4f4e\u3044\u50be\u5411\u304c\u3042\u308b\u305f\u3081\uff08\u4e73\u304c\u3093\uff09\u3001\u3053\u306e\u300c\u6392\u30ac\u30b9\u300d\u306e\u5897\u52a0\u306b\u8010\u3048\u3089\u308c\u305a\u3001\u81f4\u547d\u7684\u306a\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u307e\u3059\u3002<\/p>\n<p>2. \u81ea\u7206\u88c5\u7f6e\u306e\u8d77\u52d5\uff08\u30ab\u30b9\u30d1\u30fc\u30bc\u4f9d\u5b58\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff09<br \/>\n\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u640d\u50b7\u3057\u3001\u7d30\u80de\u5185\u306b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5145\u6e80\u3059\u308b\u3068\u3001\u7d30\u80de\u306f\u751f\u5b58\u3092\u8ae6\u3081\u3001**\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u81ea\u7206\u88c5\u7f6e\uff09**\u3092\u8d77\u52d5\u3057\u307e\u3059\u3002\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u3053\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u3001\u30ab\u30b9\u30d1\u30fc\u30bc\u3068\u3044\u3046\u9175\u7d20\u7fa4\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3057\u307e\u3059\uff08\u5c3f\u8def\u4e0a\u76ae\u304c\u3093\u3001\u81a0\u82bd\u816b\uff09\u3002<\/p>\n<p>3. \u5897\u6b96\u30fb\u8ee2\u79fb\u6307\u4ee4\u306e\u906e\u65ad\uff08\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u5236\u5fa1\uff09<br \/>\n\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u307e\u305f\u3001\u764c\u7d30\u80de\u306e\u5897\u6b96\u3084\u8ee2\u79fb\u306b\u4e0d\u53ef\u6b20\u306a\u7279\u5b9a\u306e\u300c\u6307\u4ee4\u7cfb\u7d71\u300d\u3092\u906e\u65ad\u3057\u307e\u3059\u3002<\/p>\n<p>\u2022 \u5897\u6b96\u6307\u4ee4\u306e\u505c\u6b62\uff08Akt\/mTOR\uff09: \u81a0\u82bd\u816b\u306a\u3069\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u306e\u6210\u9577\u3068\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308bAkt\/mTOR\u7d4c\u8def\u3092\u30aa\u30d5\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u5897\u6b96\u3092\u6291\u5236\u3057\u307e\u3059\u3002<br \/>\n\u2022 \u8ee2\u79fb\u6307\u4ee4\u306e\u505c\u6b62\uff08Wnt\/JNK\uff09: \u5185\u5206\u6ccc\u62b5\u6297\u6027\u4e73\u304c\u3093\u3067\u306f\u3001\u7d30\u80de\u306e\u79fb\u52d5\u30fb\u6d78\u6f64\u3092\u4fc3\u3059Wnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u53d7\u5bb9\u4f53\u3084\u30ea\u30ac\u30f3\u30c9\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u8ee2\u79fb\u80fd\u529b\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u5c3f\u8def\u4e0a\u76ae\u304c\u3093\u3067\u306f\u3001\u7d30\u80de\u751f\u5b58\u306b\u95a2\u308f\u308bJNK\u7d4c\u8def\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u30a4\u30d9\u30eb\u30e1\u30af\u30c1\u30f3\u306f\u764c\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u3092\u65ad\u3061\u3001\u81ea\u7206\u30b9\u30a4\u30c3\u30c1\u3092\u62bc\u3057\u3001\u3055\u3089\u306b\u5897\u6b96\u3068\u8ee2\u79fb\u306e\u6307\u4ee4\u4f1d\u9054\u3092\u59a8\u5bb3\u3059\u308b\u3068\u3044\u3046\u591a\u89d2\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u3001\u524d\u81e8\u5e8a\u30ec\u30d9\u30eb\u3067\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3010\u30bd\u30fc\u30b9\u8ad6\u6587\u3011<br \/>\nhttps:\/\/www.osti.gov\/biblio\/22696697<\/p>\n<p>https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2797483<\/p>\n<p>https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2021.741623\/full<\/p>\n<p>https:\/\/bezmialemscience.org\/articles\/ivermectin-induces-oxidative-stress-and-dna-damage-in-breast-cancer-cells\/bas.galenos.2022.54254<\/p>\n<p>https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0326742<\/p>\n<p>https:\/\/academic.oup.com\/jac\/article\/75\/4\/827\/5710696?utm_source=chatgpt.com&#038;login=false<\/p>\n<p>https:\/\/www.oncotarget.com\/article\/21435\/<\/p>\n<p>https:\/\/www.medsci.org\/v19p1567.pdf<\/p>","protected":false},"excerpt":{"rendered":"<p>\u3010\u30bd\u30fc\u30b9\u3092\u5fe0\u5b9f\u306bAI\u3092\u4f7f\u7528\u3057\u3066\u89e3\u8aac\u3059\u308b\u52d5\u753b\u3067\u3059\u3011 \u4eca\u56de\u306f\u30018\u672c\u306e\u8ad6\u6587\u304b\u3089\u30a4\u30d9\u30eb\u30e1&#8230; 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